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CBG Side Effects: Learn the Potential Risks of this Cannabinoid

Published on August 6, 2024
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Key points

  • Cannabigerol (CBG) is a precursor cannabinoid found in young cannabis plants and serves as the "mother" to other cannabinoids like THC and CBD.
  • CBG has shown potential in reducing inflammation, providing neuroprotection, combating bacterial infections, stimulating appetite, and potentially inhibiting unwanted cell growth.
  • Common side effects of CBG are generally mild and can include dry mouth, lower blood pressure, and reduced appetite.
  • The novel hemp plant cannabinoid, cannabigerol, may interact with other medications and should be used cautiously, especially in high doses.

Cannabigerol (CBG) is a newer cannabinoid found in the cannabis sativa plant. Although it is less well-known than other cannabinoids like CBD and THC, it is gaining attention for its potential therapeutic benefits. As scientific research on CBG continues to progress, it is becoming increasingly important to understand its effects on the human body, its potential health benefits, and any potential side effects.

This comprehensive guide explores the multifaceted nature of CBG, examining its potential therapeutic applications, interactions with the body’s endocannabinoid system, and considerations for its consumption in various forms.

CBG: The Mother of Cannabinoids

Cannabigerol (CBG) is a non-psychoactive cannabinoid found in the cannabis plant. Often referred to as the “mother of cannabinoids,” CBG is the precursor from which other cannabinoids like THC and CBD are derived. In young cannabis plants, CBG exists in its acidic form, cannabigerolic acid (CBGA), which converts into CBG through the process of decarboxylation. This conversion is crucial for the synthesis of other cannabinoids, making CBG a foundational component of the cannabis plant.

Cannabigerolic Acid (CBGA)

CBGA is the acidic form of CBG and is the precursor to THCA, CBDA, and CBCA, the acidic forms of THC, CBD, and CBC, respectively. The enzymes in cannabis plants convert CBGA into these cannabinoids, which then transform into their active forms (THC, CBD, CBC) through decarboxylation (heat or UV light exposure).

Potential Side Effects of CBG

While CBG is generally well-tolerated, some users may experience side effects. These are typically mild and can include:

  • Dry Mouth: CBG may reduce saliva production, leading to dry mouth, a common side effect shared with other cannabinoids.
  • Lower Blood Pressure: CBG has been noted to potentially lower blood pressure, which may cause lightheadedness or dizziness in some individuals.
  • Reduced Appetite: Although CBG can stimulate appetite in some cases, it has also been observed to reduce appetite in others, especially at higher doses.

Potential Risks and Interactions

  1. Mixing with Other Medications: CBG may interact with prescription medications, particularly those metabolized by the liver. It is crucial to consult a doctor before taking CBG, especially if you are on other medications.
  2. Avoiding High Doses: Higher concentrations of CBG can increase the risk of adverse effects. It is recommended to start with low doses and gradually increase as needed.
  3. More Research Needed: Despite the promising preliminary studies, more research is needed to understand the long-term effects and potential risks of CBG fully.

Potential Benefits of CBG

1. Anti-Inflammatory Effects

CBG has demonstrated significant anti-inflammatory properties, particularly in conditions like inflammatory bowel disease (IBD). Studies have shown that CBG can reduce inflammation by interacting with cannabinoid receptors in the body’s endocannabinoid system, which plays a crucial role in regulating immune responses.

2. Neuroprotective Properties

Preliminary studies suggest that CBG has neuroprotective effects, making it a potential therapeutic agent for neurodegenerative diseases such as Huntington’s disease and multiple sclerosis. CBG’s ability to interact with cannabinoid receptors in the central nervous system helps protect nerve cells from damage and supports overall nervous system health.

3. Antibacterial Properties

CBG has exhibited strong antibacterial properties, effective even against drug-resistant bacteria like MRSA (methicillin-resistant Staphylococcus aureus). This makes CBG a promising candidate for developing new antibacterial treatments, potentially offering an alternative to traditional antibiotics.

4. Appetite Stimulation

CBG is known to be a well-tolerated appetite stimulant, which can be beneficial for individuals with reduced appetite due to medical conditions or treatments who are struggling to increase appetite. Unlike THC, which often leads to strong appetite stimulation (known as the “munchies”), CBG provides a more balanced appetite boost.

5. Anti-Nausea and Cell Health Potential

Like CBD, CBG has shown promise in reducing nausea and vomiting, which can be particularly helpful for patients undergoing chemotherapy. Additionally, research indicates that CBG may inhibit the unwanted growth of cells, particularly in colon carcinogenesis. While these findings are promising, more research is needed to confirm the potential of CBG.

How CBG Works in the Body

CBG interacts with the body’s endocannabinoid system (ECS), which regulates various physiological processes such as physical discomfort, appetite, mood, and immune response. By binding to cannabinoid receptors (CB1 and CB2), CBG can influence these processes and contribute to overall wellness.

Cannabinoid Receptors (CB1 and CB2)

  • CB1 Receptors: Primarily found in the brain and central nervous system, influencing pain perception, mood, and memory.
  • CB2 Receptors are located mainly in the immune system and peripheral tissues and play a role in inflammation and immune response.

Purchasing and Consuming CBG

When purchasing CBG products, it is essential to ensure they come from reputable sources to avoid harmful chemicals and contaminants. Whether for physical relief or anxiety support, look for CBG oil, capsules, and other products that are clearly labeled with their CBG content and have undergone third-party testing for purity and potency.

Consumption Methods

  • CBG Oil: Can be taken sublingually (under the tongue) for quick absorption or added to food and drinks.
  • Capsules: Provide a convenient and precise dosage.
  • Topicals: Applied directly to the skin for localized relief of joint and muscle discomfort, and inflammation.

Final Thoughts: CBD Effects and Benefits

CBG holds significant potential in cannabinoid therapy. CBG may help with chronic physical aches, anxiety, and sleep, but the research is still ongoing. Its anti-inflammatory, neuroprotective, antibacterial, and appetite-stimulating properties make it a promising candidate for various therapeutic applications. However, as with any supplement, it is vital to approach CBG with informed caution, understanding its potential side effects and interactions with other conventional medicines. As research progresses, CBG may well become a cornerstone in the treatment of numerous conditions, contributing to the overall wellness and health of individuals worldwide. Always consult with a healthcare provider before starting any new treatment involving cannabinoids.

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Other Topics You Might Want To Read:

References:

  1. Effects of Cannabinoids, CBG, on TRP Systems
  2. CBG’s Effects on Anti-Nausea
  3. Delta-8-THC: Delta-9-THC’s nicer younger sibling?
  4. Consumer Experiences with Delta-8-THC
  5. Hemp Production and the 2018 Farm Bill – 07/25/2019 | FDA
  6. The Controlled Substances Act (dea.gov)

FAQs About CBG Effects

Are CBG products generally well-tolerated?

Yes, CBG products are generally well-tolerated, and some users have reported mild side effects, primarily dry mouth.

Are there any known interactions of CBG with prescription medications?

CBG may interact with certain prescription medications metabolized by the liver. So, avoid mixing CBG with any medication, and consult with a healthcare provider.

Is CBG effective against drug-resistant bacteria?

Preliminary studies suggest CBG may have antibacterial properties, including efficacy against drug-resistant bacteria like MRSA.

How does CBG affect bladder contractility?

Studies suggest that CBG may influence bladder contractility, potentially offering benefits in conditions involving bladder dysfunction. Research in this area is still in its early stages, and more studies are needed to confirm these effects in human trials.

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